| Hsp70 Family | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| APG-1 | HspA4L, Osp94 | 22824 | O95757 | Hsp110-subfamily | |
| APG-2 | HspA4, Irp94, Hsp70RY | 3308 | P34932 | Hsp110-subfamily; phosphorylated upon DNA damage, probably by ATM or ATR | |
| BIP/Grp78 | HspA5, Hsp70-5 | 3309 | P11021 | Constitutively expressed ER form of Hsp70, also referred to as 'immunoglobulin heavy chain binding protein' | Antibodies (SPA-826, SPA-827), Protein (SPP-765) |
| Grp75/ Mortalin | MtHsp70, HspA9, Hsp70-9, MOT, Mot-2 | 3313 | P38646 | Mitochondrial form of Hsp70; constitutively expressed; cooperates with Hsp60 to fold preproteins following transit across mitochondrial membrane | Antibody (SPS-825) |
| Hsc70 | HspA8, Hsp70-8, Hsp73, Hsc71 | 3312 | P11142 | Constitutively expressed in most tissues; essential housekeeping gene; two isoforms due to alternative splicing | Antibodies (SPA-815, SPA-816), Proteins (SPP-751, SPP-752) |
| Hsp70-4 | Hsp70L1 HspA14 | 51182 | Q0VDF9 | Hsp70-like protein 1; cloned from human dendritic cells | |
| Hsp70B | HspA7 | 3311 | P48741 | Tightly linked to Hsp70B' locus | |
| Hsp70B' | HspA6, Hsp70-6 | 3310 | P17066 | Strictly stress-inducible; in unstressed conditions it is expressed only in certain blood cells (dendritic cells, monocytes and NK cells) | ELISA (EKS-725), Antibodies (SPA-756, SPA-754), Protein (SPP-762) |
| Hsp70-Hom | HspA1L, Hum70t, Hsp70-1t | 3305 | P34931 | Constitutive, testis-specific expression; locus adjacent to Hsp72 and Hsp70-2 | |
| Hsp72 | HspA1A, Hsp70-1a, Hsp70-1 | 3303 | P08107 | Stress-inducible; highly expressed in various cancers; corrlelated with increased proliferation, metastasis and poor outcome in breast cancer | ELISA (EKS-700), Antibodies (SPA-810, SPA-812), Proteins (ESP-555, SPP-758) |
| Hsp72 | HspA1B, Hsp70-1b, Hsp70-1 | 3304 | P08107 | Stress-inducible; identical in protein sequence to HspA1A above, but transcribed from an adjacent locus | ELISA (EKS-700), Antibodies (SPA-810, SPA-812), Proteins (ESP-555, SPP-758) |
| Hsp110 | Hsp105, HspH1 | 10808 | Q92598 | Hsp110-subfamily; acts as nucleotide exchange factor for Hsp70 | Antibodies (SPA-1101, SPA-1103) |
| HspA2 | Hsp70-2 | 3306 | P54652 | Constitutively expressed at high levels in brain and testis; role in spermatogenesis; upregulated in a subset of breast cancers and has growth and survival promoting effects in cancer cells | Protein (ESP-502) |
| HYOU1 | Hypoxia upregulated 1, Grp170, ORP 150 | 10525 | Q9Y4L1 | Induced by hypoxia, found in the ER, upregulated in tumors; protein with alternative translation start site found in the cytoplasm | |
| Hsp70/Hsp40 Associated Co-chaperones & Others | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| Bag-1 | HAP | 573 | Q99933 | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release; two splice variants | Antibodies (AAM-400, 905-735) |
| Bag-2 | NA | 9532 | O95816 | Associates with CHIP and inhibits/regulates its activity by inhibiting the interaction between CHIP and its cognate ubiquitin-conjugating enzyme, UbcH5a; phosphorylated at Ser20 by MAPKAPK-2 | |
| Bag-3 | BIS | 9531 | O95817 | Binds ATPase domain of Hsp70/Hsc70, inhibits chaperone activity | |
| Bag-4 | SODD | 9530 | O95429 | Inhibits Hsp70/Hsc70; prevents constitutive TNFRSF1A signaling; cytosolic | |
| Bag-5 | NA | 9529 | Q9UL15 | Negative regulator of Hsp70; two alternative splice forms | |
| BAP | SIL1 | 64374 | Q9H173 | ER localized protein that is associated with BiP/Grp94 and serves as a nucleotide exchange factor for it; mutations associated with Marinesco-Sjogren syndrome; two splice variants that encode the same protein | |
| CHIP | STUB1, UBOX1, HSPABP2 | 10273 | Q9UNE7 | Carboxyl terminus of Hsp70 Interacting Protein; an Hsp70-associated E3 ubiquitin ligase that targets chaperone substrates to the proteasome; inhibited by Hip and BAG-2; interacts with HSF1 upon heat shock; substrates include AR, Tau, Smad1/4, nNOS and Cu/Zn-SOD | |
| Hip | HspBP1 | 23640 | Q9NZL4 | Nucleotide exchange factor for Hsp70; inhibits the ubiquitin ligase activity of CHIP; an anti-apoptotic protein and substrate of Granzyme B | Antibody (SPA-766), Protein (SPP-767) |
| Hop | STIP1, STI1 | 10963 | P31948 | Hsp70/Hsp90-organizing protein; Stress-induced Phosphoprotein 1; binds EEVD motifs at the C-termini of Hsp70 and Hsp90; also binds Cdc37; normally found in the cytoplasm, but also seen in the nucleus depending on cell cycle/CDK activity | Antibody (SRA-1500), Protein (SRP-1510) |
| Hsp40/DnaJ Family | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| CSP | Cysteine String Protein, DnaJC5 | 80331 | Q9H3Z4 | Secretory vesicle protein involved in regulated exocytosis; plays a role in CFTR biogenesis and trafficking; interacts with the inactive GDP-bound form of Galpha(s) and promotes GDP/GTP exchange; guanine nucleotide exchange activity regulated by Hsc70 and SGT | Antibody (VAP-SV003) |
| CSP-beta | DnaJC5B | 85479 | Q9UF47 | Testis specific expression; palmitoylated | |
| CSP-gamma | DnaJC5G | 285126 | Q8N7S2 | Testis specific expression; palmitoylated | |
| DnaJA4 | NA | 55466 | Q8WW22 | Hsp40 homolog | |
| DnaJA5 | NA | 134218 | Q5F1R6 | Hsp40 homolog; three splice variants; expressed in brain, placenta, kidney, and pancreas | |
| DnaJB12 | NA | 54788 | Q9NXW2 | Possibly membrane-associated | |
| DnaJB13 | TSARG6 | 374407 | P59910 | Expressed specifically in adult testis, implicated in apoptosis in spermatogenic cells | |
| DnaJB14 | NA | 79982 | Q8TBM8 | Possibly membrane-associated; two splice variants | |
| DnaJB8 | NA | 165721 | Q8NHS0 | Hsp40 homolog | |
| DnaJC11 | FLJ10737 | 55735 | Q9NVH1 | Candidate tumor suppressor gene of neuroblastoma; found in mitochondria | |
| DnaJC16 | NA | 23341 | Q9Y2G8 | Possibly type IV single-pass membrane protein; two splice variant | |
| DnaJC17 | NA | 55192 | Q9NVM6 | Hsp40 homolog; contains RNA recognition motif | |
| DnaJC18 | NA | 202052 | Q9H819 | Possibly single-pass membrane protein | |
| DnaJC19 | TIM14 | 131118 | Q96DA6 | Mitochondrial protein, similar in sequence to yeast Tim14 which is involved in mitochondrial protein import; mutated in DCMA syndrome (dilated cardiomyopathy with ataxia) | |
| DnaJC4 | HSPF2; MCG18 | 3338 | Q9NNZ3 | Possibly single-pass membrane protein | |
| DnaJC6 | DJC6 | 9829 | O75061 | Involved in uncoating of clathrin coated vesicles; interacts with Hsc70; three splice variants | |
| DnaJC7 | TPR2; TTC2 | 7266 | Q99615 | Interacts with GAP domain of NF1 | |
| DnaJC8 | SPF31 | 22826 | O75937 | Splicing protein spf31 | |
| DRIP78 | HDJ3; DnaJC14 | 85406 | Q6Y2X3 | May regulate trafficking of GPCR's including Angiotensin II and Dopamine Receptor; may play a role as a chaperone in the assembly of G-beta/gamma subunits | |
| ERdj3 | DnaJB11, ERj3, HEDJ; ABBP-2 | 51726 | Q9UBS4 | ER localized, expression induced by ER stress; stimulates BiP ATPase activity | |
| ERdj5 | JPDI; DnaJC10 | 54431 | Q8IXB1 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family | |
| Hdj2 | DnaJA1, DJ2; DJA1; HSDJ; HSJ2 | 3301 | P31689 | Farnesylated; interacts with Hsc70; two splice forms, one nuclear, one expressed throughout the cell | |
| HdjC9 | JDD1; DnaJC9 | 23234 | Q8WXX5 | Hsp40 homolog | |
| Hlj1 | DnaJB4, DjB4; DnaJW | 11080 | Q9UDY4 | Identified in human liver | |
| HSC3 | DnaJB7 | 150353 | Q7Z6W7 | ER localized, expression induced by ER stress (UPR); also a member of the Protein Disulfide Isomerase family | |
| Hsc40 | DnaJB5 | 25822 | O75953 | Constitutive Hsp40 isoform | |
| HscB | DnaJC20, Jac1, Hsc20 | 150274 | Q8IWL3 | Homolog of E. coli HscB, which along with the E. coli Hsp70 homolog HscA forms part of a specialized system for synthesizing iron-sulfur proteins; candidate gene in hereditary ataxia syndromes | |
| Hsj1 | DnaJB2, HSPF3 | 3300 | P25686 | Neuronal tissue-specific; two isoforms (Hsj1a and Hsj1b) | |
| Hsp40/Hdj1 | DnaJB1, HSPF1 | 3337 | P25685 | Enhances ATPase activity of Hsp70 family members | Antibodies (SPA-400, SPA-450), Protein (SPP-400) |
| Htj1/ERdj1 | DNAJC1, DNAJL1, MTJ1 | 64215 | Q96KC8 | Enriched in microsomes and nucleus; stimulates BiP ATPase activity; involved in transport of BiP to the cell surface | |
| JDP1 | DnaJC12 | 56521 | Q9UKB3 | An estrogen target gene, highly expressed in ER positive breast cancer; two isoforms; conserved down to Drosophila | |
| MCJ | HSD18, DNAJD1, DNAJC15 | 29103 | Q9Y5T4 | Methylation controlled J protein (MCJ) is a type II transmembrane cochaperone localized in the Golgi network and present only in vertebrates | |
| Mdg1/ERdj4 | DnaJB9 | 4189 | Q9UBS3 | ER localized, expression induced by UPR; expression associated with low metastatic potential; stimulates BiP ATPase activity | |
| MPP11 | MIDA1, DnaJC2, Zrf1, Zrf2 | 22791 | P54103 | Localized to nucleus; ubiquitously expressed | |
| Mrj | DnaJB6, Hsj2; Msj1 | 10049 | O75190 | Enriched in the CNS; two isoforms as a result of alternative splicing; one nuclear, one expressed throughout the cell; binds and regulates NFAT | |
| P58(IPK) | DnaJC3, PRKRI; | 5611 | Q13217 | Binds and inactivates PKR; induced by ER stress, binds and inactivates PERK | |
| Rdj2 | DnaJA2, DJA2 | 10294 | O60884 | Hsc70 co-chaperone; possibly membrane-associated and farnesylated | |
| RME-8 | DnaJC13 | 23317 | O75165 | Functions in endosomal trafficking; human homolog of Receptor-mediated endocytosis 8 (RME8) in C. elegans; widely expressed, binds Hsc70 | |
| Tid1 | hTid-1, DnaJA3 | 9093 | Q96EY1 | Mitochondrial; modulates apoptotic signal transduction, cytochrome c release, and caspase 3 activation; two splice variants | |
| Hsp60/Hsp10 Family | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| CCT2 | chaperonin containing TCP1 subunit 2 (beta), TCP1-beta, CCTB, CCT-beta; | 10576 | P78371 | Component of hetero-oligomeric TRiC complex | |
| CCT3 | chaperonin containing TCP1 subunit 3 (gamma), CCTG, CCT-gamma, TRIC5, TCP1-gamma | 7203 | P49368 | Component of hetero-oligomeric TRiC complex; three alternative splice forms | |
| CCT4 | chaperonin containing TCP1 subunit 4 (delta), SRB, CCTd | 10575 | P50991 | Component of hetero-oligomeric TRiC complex | |
| CCT5 | chaperonin containing TCP1 subunit 5 (epsilon), CCTE, CCT-epsilon, TCP1-epsilon | 22948 | P48643 | Component of hetero-oligomeric TRiC complex; mutation associated with autosomal recessive mutilating sensory neuropathy with spastic paraplegia; expression up-regulated in p53-mutated tumors | |
| CCT6A | chaperonin containing TCP1 subunit 6A (zeta 1), CCT6, CCTz, HTR3, TCPZ, TCP20, MoDP-2, TTCP20, CCT-zeta, CCT-zeta1, TCP1-zeta | 908 | P40227 | Component of hetero-oligomeric TRiC complex; ionizing radiation results in enhanced expression in radioresistant cancer cells compared to radiosensitive cells; two alternative splice forms | |
| CCT6B | chaperonin containing TCP1 subunit 6B (zeta 2), CCT-zeta2; TCP1-zeta2 | 10693 | Q92526 | Component of hetero-oligomeric TRiC complex; tesis specific expression | |
| CCT7 | chaperonin containing TCP1 subunit 7 (eta), HIV-1 Nef interacting protein ( Nip7-1), TCP1-eta, Ccth, CCT-Eta | 10574 | Q99832 | Component of hetero-oligomeric TRiC complex; two alternative splice forms | |
| Hsp10 | CPN10, GroES, HSPE1 | 3336 | P61604 | Closely linked to the Hsp60 gene (HspD1); forms chaperonin 'cap' structure | Antibody (SPA-110), Protein (SPP-110) |
| Hsp60 | HspD1, CPN60, GroEL, HSP65, SPG13, HuCHA60 | 3329 | P10809 | Mitochondrial protein essential for folding and assembly of newly imported proteins; also a signaling molecule in the innate immune system; mutations associated with autosomal recessive spastic paraplegia | ELISA (EKS-600), Antibodies (SPA-806, SPA-829, SPA-828), Proteins (ESP-540, ESP-741, SPP-742) |
| TCP1 | CCT1, CCT-alpha, TCP1-alpha | 6950 | P17987 | Member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC), consisting of two identical stacked rings, each containing eight different proteins; the complex folds various proteins, including actin and tubulin, in an ATP-dependent manner; two alternative splice forms;unlike Hsp60, no known associated Hsp10/GroES cofactor | |
| Hsp90 Family | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| Grp94 | Hsp90B1, Gp96 | 7184 | P14625 | ER form; glucose regulated and induced by glucose starvation; participates in protein folding and assembly, protein secretion, protecting cells from apoptosis, and mediating immunogenicity; C-terminal sequence KDEL mediates retention in the ER; two splice variants |
Antibodies (SPA-850, SPA-851, SPA-827), Protein (SPP-766) |
| Hsp90 alpha | Hsp90AA1, Hsp86, Hsp89 | 3320 | P07900 | Cytosolic form, induced by elevated temperature; ATPase activity; three splice variants | ELISA (EKS-895), Antibodies (SPS-771, SPA-840), Protein (SPP-776) |
| Hsp90 alpha | Hsp90AA2 | 3324 | Q14568 | Cytosolic form, induced by elevated temperature | |
| Hsp90 beta | Hsp90AB1 | 3326 | P08238 | Cytosolic form, constitutively expressed; ATPase activity; three splice variants | Antibodies (SPA-843, SPA-842) |
| TRAP1 | Hsp75 | 10131 | Q12931 | Mitochondrial form; has ATPase activity that is inhibited by both geldanamycin and radicicol; highly conserved through evolution; phosphorylation by PINK1 prevents oxidative-stress-induced apoptosis; four splice variants | |
| Hsp90 Associated Co-chaperones & Others | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| Aha1 | Activator of Hsp90 ATPase homolog 1 | 10598 | O95433 | Stimulates the inherent ATPase activity of Hsp90 | |
| Cdc37 | NA | 11140 | Q16543 | A chaperone that binds Hsp90 and is required for the activity of numerous protein kinases | |
| Hop | STIP1, STI1 | 10963 | P31948 | Golgi; Hsp70/Hsp90-organizing protein; Stress-induced Phosphoprotein 1; binds EEVD motifs at the C-termini of Hsp70 and Hsp90; also binds Cdc37; normally found in the cytoplasm, but also seen in the nucleus depending on cell cycle/CDK activity | Antibody (SRA-1500), Protein (SRP-1510) |
| p23 | TEBP, PGE Synthase 3 | 10728 | Q15185 | Binds to telomerase and progesterone receptor; also functions as a cytosolic prostaglandin E2 synthase; phosphorylated at Ser113, 118, 148 and 151 and acetylated at Lys33 | Antibody (SPA-670), Protein (SPP-670) |
| Small Hsp Family (sHsps) | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| Crystallin, alpha A | CRYAA, CRYA1, HSPB4 | 1409 | P02489 | Expression restricted to the lens | Antibody (SPA-221), Protein (SPP-226) |
| Crystallin, alpha B | CRYAB, CRYA2, HSPB5 | 1410 | P02511 | Broad tissue expression; elevated expression in many neurological diseases; a missense mutation associated with a desmin-related myopathy | Antibodies (SPA-222, SPA-223, SPA-225, SPA-226, SPA-227), Protein (SPP-227) |
| Heat shock 22kDa protein 8 | H11, E2IG1, HSP22, HSPB8 | 26353 | Q9UJY1 | Charcot-Marie-Tooth disease type 2L; Hereditary motor neuropathy type II | |
| heat shock 27kDa protein 1 | Hsp27, Hsp25, HSPB1 | 3315 | P04792 | Charcot-Marie-Tooth disease, axonal, type 2F; distal hereditary motor neuropathy | ELISA (EKS-500), Antibodies (SPA-801, SPA-803, SPA-800, SPA-525, SPA-523, SPA-524, 905-642), Proteins (NSP-510, ESP-715, SPP-716) |
| heat shock 27kDa protein 2 | HSPB2, MKBP | 3316 | Q16082 | Associates with myotonic dystrophy protein kinase (DMPK) | |
| heat shock 27kDa protein 3 | HSPB3, HSPL27 | 8988 | Q12988 | Inhibitor of actiin polymerization | |
| heat shock 27kDa protein family, member 7 (cardiovascular) | cvHSP, HspB7 | 27129 | Q9UBY9 | Bovine βH-crystallin | |
| heat shock protein, alpha-crystallin-related, B6 | HSPB6, Hsp20 | 126393 | O14558 | Structural component of eye lens | Antibody (SPA-796) |
| heat shock protein, alpha-crystallin-related, B9 | HSPB9, CT51 | 94086 | Q9BQS6 | Testis specific | |
| outer dense fiber of sperm tails 1 | HSPB10, ODFP, SODF, ODF1 | 4956 | Q14990 | Component of outer dense fibers of spermatozoa; testis specific expression | |
| Beta/gamma Crystallin family | |||||
| Crystallin, beta A1 | CRYBA1 | 1411 | P05813 | Mutation causes the autosomal dominant disease 'zonular cataract with sutural opacities'; member of the acidic group of beta crystallins; beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins | Antibody (SPA-230; not known which beta family members are recognized by this antibody), Proteins (SPP-235, SPP-236; not known which beta family members are represented in these native preparations) |
| Crystallin, beta A2 | CRYBA2 | 1412 | P53672 | Member of the acidic group of beta crystallins | |
| Crystallin, beta A4 | CRYBA4 | 1413 | P53673 | Member of the acidic group of beta crystallins; part of a gene cluster with beta B1, beta B2, and beta B3; mutations linked to cataractogenesis and microphthalmia | |
| Crystallin, beta B1 | CRYBB1 | 1414 | P53674 | Member of the basic group of beta crystallins | |
| Crystallin, beta B2 | CRYBB2 | 1415 | P43320 | Member of the basic group of beta crystallins; mutation found to cause type 2 cerulean cataracts | |
| Crystallin, beta B3 | CRYBB3 | 1417 | P26998 | Member of the basic group of beta crystallins | |
| Crystallin, gamma A | CRYGA, CRYG1, CRYG5 | 1418 | P11844 | Part of a gene cluster with gamma B, C and D, and the pseudogenes gamma-E, F and G; gamma-crystallins are monomeric proteins and have been implicated in cataract formation | Protein (SPP-240; not known which gamma family members are represented in this native preparation) |
| Crystallin, gamma B | CRYGB, CRYG2 | 1419 | P07316 | Part of a gene cluster with gamma A, C and D, and the pseudogenes gamma-E, F and G; gamma-crystallins are monomeric proteins and have been implicated in cataract formation | |
| Crystallin, gamma C | CRYGC, CRYG3, CCL | 1420 | P07315 | Part of a gene cluster with gamma A, B, and D, and the pseudogenes gamma-E, F and G; gamma-crystallins are monomeric proteins and have been implicated in cataract formation | |
| Crystallin, gamma D | CRYGD, CRYG4, CCP, PCC, CACA, CCA3 | 1421 | P07320 | Part of a gene cluster with gamma A, B, and C, and the pseudogenes gamma-E, F and G; gamma-crystallins are monomeric proteins and have been implicated in cataract formation | |
| Crystallin, gamma N | CRYGN | 155051 | Q496G6 | beta-gamma hybrid crystallin; expressed in retina and lens nuclear fibers in rodents | |
| Crystallin, gamma S | CRYGS, CRYG8 | 1427 | P22914 | The most significant gamma-crystallin in adult eye lens tissue | |
| Other Hsps and Chaperones | |||||
| Name | Synonyms | Entrez Gene ID | SwissProt ID | Function/Structure | Related Products |
| Calnexin | CNX, P90 | 821 | P27824 | Calcium-binding ER protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly; it may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation | Antibodies (SPA-860, SPA-865) |
| Calreticulin | CRTC, ERp60, grp60 | 811 | P27797 | Calcium-binding ER protein; also found in the nucleus; can bind and inhibit nuclear hormone receptors | Antibodies (SPA-600, SPA-601) |
| CHIP | STUB1, UBOX1, HspABP2 | 10273 | Q9UNE7 | E3 ubiquitin ligase; co-chaperone that associates with Hsp70 and Hsp90 | |
| HO-1 | heme oxygenase (decyclizing) 1, HMOX1, Hsp32 | 3162 | P09601 | Highly inducible by heavy metals, endotoxin, oxidizing agents, UVA; cleaves heme ring at the alpha methene bridge to form biliverdin | ELISA (EKS-800, EKS-810), Antibodies (SPA-895, SPA-896, OSA-150, OSA-110, OSA-111), Proteins (SPP-730, SPP-732) |
| HO-2 | heme oxygenase (decyclizing) 2, HMOX2 | 3163 | P30519 | Non-inducible; cleaves heme ring at the alpha methene bridge to form biliverdin | Antibodies (OSA-200, SPA-897), Proteins (NSP-550) |
| HSF-1 | HSTF1 | 3297 | Q00613 | Regulates the program of heat shock gene expression. Expression repressed by Hsp90; positively and negatively regulated by phosphorylation; modified by SUMO-1 and SUMO-2 in a stress-inducible manner | Antibodies (SPA-950, SPA-901), Protein (SPP-900) |
| HSF-2 | HSTF2 | 3298 | Q03933 | Regulates the program of heat shock gene expression | Antibody (SPA-960) |
| Hsp47 | SerpinH1, Colligin, Gp46 | 871 | P50454 | ER-localized member of the serpin family of serine protease inhibitors; expression induced by heat shock; binds collagen and thought to be a chaperone involved in the maturation of collagen; autoantibodies found in patients with rheumatoid arthritis | Antibody (SPA-470), Protein (NSP-535) |
| KDELR1 | ERD2 | 10945 | P24390 | Family of seven-transmembrane receptors that mediate the retention of proteins with the sequence lys-asp-glu-leu (KDEL), such as Grp78 and Grp94, in the lumen of the ER | Antibody (VAA-PT048) |
| KDELR2 | ERD2.2 | 11014 | P33947 | Two alternative splice forms | |
| KDELR3 | ERD2L3 | 11015 | O43731 | Two alternative splice forms | |
| UGGT | UDP-glucose:glycoprotein glucosyltransferase, HUGT1, UGCGL1, GT, UGT1, UGTR | 56886 | Q9NYU2 | Recognizes glycoproteins with minor folding defects; reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum; reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation | Antibody (VAP-PT068) |
| Protein Disulfide Isomerase (PDI) Family | |||||
| ERdj5 | JPDI; DnaJC10 | 54431 | Q8IXB1 | Expression induced by ER stress; also a member of the DnaJ family | |
| ERp18 | TXNDC12, AGR1, ERp19 | 51060 | O95881 | Member of the thioredoxin superfamily; expressed in ER lumen | |
| ERp27 | NA | 121506 | Q96DN0 | Interacts with PDIA3; does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family | |
| ERp29 | ERp28, ERp31, PDI-DB | 10961 | P30040 | Similar in sequence to the PDI family, but lacks a thioredoxin motif, suggesting it does not function as a disulfide isomerase; the protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER; two alternative splice forms | |
| ERp44 | TXNDC4 | 23071 | Q9BS26 | Induced by ER stress | |
| ERp46 | TXNDC5 | 81567 | Q8NBS9 | Highly expressed in endothelial cells, where it is induced by and protects against hypoxia; contains 3 thioredoxin domains; two isoforms | |
| ERp57 | Grp58, PDIA3 | 2923 | P30101 | ER protein with protein disulfide isomerase activity that interacts with the lectin chaperones calreticulin and calnexin to modulate the folding of newly synthesized glycoproteins | Antibodies (SPA-585, SPA-725) |
| ERp72 | PDIA4, ERp70 | 9601 | P13667 | Catalyzes rearrangement of disulfide bonds | Antibody (SPS-720) |
| P5 | PDIA6, ERP5, TXNDC7 | 10130 | Q15084 | Can also function on the cell surface | |
| PDI | PDIA1, P4HB | 5034 | P07237 | Catalyzes S-S bond formation, breakage, and rearrangement in nascent (ER lumen) and cell surface proteins | |
| PDILT | 204474 | Q8IVQ5 | Testis-specific expression | ||
| PDIP | PDIA2 | 64714 | Q13087 | Catalyzes S-S bond rearrangement; expressed in ER lumen; high expression in pancreas | |
| PDIR | PDIA5 | 10954 | Q14554 | Contains 3 thioredoxin domains | |
| TMX | TXNDC1 | 81542 | Q9H3N1 | Contains one thioredoxin domain and a putative transmembrane domain | |
| TMX2 | TXNDC14 | 51075 | Q561W0 (TrEMBL ID) | Contains one thioredoxin domain and a putative transmembrane domain | |
| TMX3 | TXNDC10 | 54495 | Q96JJ7 | Contains one thioredoxin domain and a putative transmembrane domain | |
| TMX4 | TXNDC13 | 56255 | Q9H1E5 | Contains one thioredoxin domain and a putative transmembrane domain | |