Cannabinoid Receptor (CB2) Polyclonal Antibody, DY-682

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Cannabinoid Receptor (CB2) Polyclonal Antibody, DY-682 100 µg   905-819-100 $310.00
Background
The cannabinoid receptors CB1 and CB2 are members of the seven-transmembrane family of G-protein coupled receptors (GPCRs), and are named for their signaling function in response to cannabinoid drugs such as delta 9- tetrahydrocannabinol (delta 9-THC). CB1 and CB2 differ significantly in the length of their extracellular amino terminal domain, which is longer in CB1 (116 residues) than in CB2 (33 residues). The CB1 receptor is expressed primarily in the brain and neuronal tissue, and is highly conserved, exhibiting 97-98% amino acid sequence identity across human, mouse, and rat species. In contrast, expression of the CB2 receptor is absent in normal nervous tissue, with expression most prominent in immune tissue such as the spleen. In addition to delta 9-THC and its synthetic analogs, CB1 and CB2 receptors are bound by endogenous eicosanoid ligands, and signal via Gi/o proteins to regulate adenylyl cyclase activity (generally inhibitory), ion channel activation, intracellular Ca2+ levels, nitric oxide synthase activation, and immediate early gene expression. CB1 and CB2 signals in turn regulate neurological and immunological functions such as inhibition of neurotransmitter release and immune cell migration, antigen processing, and cytokine production.

Table of Abbreviations

Applications
WB

Species Reactivity
R

Shipping Information
Please allow 15 working days for delivery.

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of mouse Cannabinoid Receptor (CB2).

Host
Rabbit

Conjugate
DY-682

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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