PDI Monoclonal Antibody (1D3), DyLight 488

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
PDI Monoclonal Antibody (1D3), DyLight 488  50 µg SPA-891-488D $185.00  
PDI Monoclonal Antibody (1D3), DyLight 488  200 µg SPA-891-488F $365.00  
Background
The mammalian protein disulphide-isomerase (PDI) family encompasses several highly divergent proteins involved in the processing and maturation of secretory proteins in the ER by catalyzing the rearrangement of disulphide bonds. PDI, an abundant protein of the ER (>400uM), contains a carboxy-terminal retention signal sequence, KDEL, similar to that of BiP and Grp94. The PDI proteins are characterized by the presence of one or more domains of ~95-110 amino acids related to the cytoplasmic protein thioredoxin. All but the PDI-D subfamily are composed entirely of repeats of such domains, with at least one domain containing - and one domain lacking - a redox-active-Cys-X-X-Cys-tetrapeptide. In addition to roles as redox catalysts and isomerases, PDI proteins perform such functions as peptide binding and cell adhesion, and may conduct chaperone activities. Platelet surface thiols and disulphides play an important role in platelet responses. Catalytically active PDI resides on platelet surfaces where it mediates platelet aggregation and secretion by reducing disulfide bonds, thus exposing fibrinogen receptors in platelets.

Table of Abbreviations

Abbreviated Name
PDI mAb, DyLight 488 (1D3)

Applications
Flow

Conjugate
DyLight 488

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Synthetic peptide derived from sequence near the C-terminus of rat PDI, conjugated to KLH

Product Image(s): click to enlarge

Host
Mouse

Clone Number
1D3

Species Reactivity
H, M, R, B, C, CH, GP, HA, MO, P, RB, S, X

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
PDI Monoclonal Antibody (1D3), DyLight 488 SPA-891-488D  
PDI Monoclonal Antibody (1D3), DyLight 488 SPA-891-488F  

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Product Name Catalog#
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IgG1 Isotype Control Monoclonal Antibody (MOPC-21), PE
 		SAB-600PE
PDI Monoclonal Antibody (1D3), DyLight 488
 		SPA-891
PDI Monoclonal Antibody (1D3), PE
 		SPA-891PE
PDI Polyclonal Antibody
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Citations
Launch Citation Database

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