Calreticulin Monoclonal Antibody (FMC 75), DyLight 488

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Description Size Catalog# Price Quantity  
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488 Conjugate  50 µg SPA-601-488D $185.00  
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488 Conjugate  200 µg SPA-601-488F $365.00  
Background
The multifunctional, multi -compartmental protein Calreticulin (Crt) functions as a soluble molecular chaperone of new or misfolded proteins, as well as a Ca2+-binding protein. Most abundant in the ER lumen, Crt expression also occurs in other membrane-bound organelles, the cell surface, and extracellularly. Also known as CRP-55, calregulin and HACBP (high affinity calcium-binding protein), Crt contains the ER-retrieval sequence, KDEL, and is the solub le paralog of the ER membrane protein Calnexin (Cnx). Crt¿s three domains include a 180 residue N-terminal domain, a proline-rich Pdomainresidues 189 -288) that binds Ca2+ with high affinity and shares homology with Cnx and calmegin, and a 110 residue C-terminal domain that binds Ca2+ with low affinity but high capacity. The P-domain may interact with the co-chaperone ERp57 (Grp58), a thiol reductase. The NMR structure of the P -domain consists of an extended hairpin that appears to form a curved protrusion from the Crt core domain. Both Crt and its membrane bound homolog CNX interact with proteins and glycoproteins possessing monoglucosylated N -glycans. The Crt/Cnx cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligomerization, regulates ER degradation, and prevents incompletely folded glycoproteins from exiting to the Golgi complex. Crt also appears to function as an auto-antigen in systemic lupus erythematosus, rheumatoid arthritis, celiac disease, complete congenital heart block, and halothane hepatitis. A diversity of additional functions attributed to Crt includes adhesion, blood function, and cardiac and neuronal development gene expression.

Table of Abbreviations

Abbreviated Name
Calreticulin mAb, DyLight 488 (FMC 75)

Conjugate
DyLight 488

Applications
Flow

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Recombinant Calreticulin Protein

Host
Mouse

Clone Number
FMC 75

Product Image(s): click to enlarge

Source
Mouse mAb

Species Reactivity
H, MO

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488 Conjugate SPA-601-488D  
Calreticulin Monoclonal Antibody (FMC 75), DyLight 488 Conjugate SPA-601-488F  

Related Products

Product Name Catalog#
Calnexin Polyclonal Antibody
 		SPA-860
Calnexin Polyclonal Antibody
 		SPA-865
Calreticulin Monoclonal Antibody (FMC 75), PE
 		SPA-601PE
Calreticulin Polyclonal Antibody
 		SPA-600
Calreticulin Recombinant Human Protein
 		SPP-600
IgG1 Isotype Control Monoclonal Antibody (MOPC-21), DyLight 488
 		SAB-600-488

Citations
Launch Citation Database

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