Hsp60 Monoclonal Antibody (LK-2), PE Conjugate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp60 Monoclonal Antibody (LK-2), PE Conjugate  50 µg SPA-807PED $235.00  
Hsp60 Monoclonal Antibody (LK-2), PE Conjugate  200 µg SPA-807PEF $395.00  
Background
The human Hsp60 belongs to a family of molecular chaperones that is highly conserved across species such as plant Hsp60 (known as Rubisco binding protein), the E. coli Hsp60 GroEL, and the 65kDa major antigen of mycobacteria. In eukaryotes, Hsp60 is localized in the mitochondrial matrix, and the plant Hsp60 in the chloroplast. Hsp60s from divergent species share a number of common characteristics: high abundance; induction with environmental stress such as heat shock; homo-oligomeric structures of either 7 or 14 subunits which reversibly dissociate in the presence of Mg2+ and ATP; ATPase activity; and a role in folding and assembly of oligomeric protein structures. These similarities correspond with studies in which the single-ring human mitochondrial homolog Hsp60 and its co-chaperonin Hsp10 were expressed in an E. coli strain engineered to keep the groE operon under strict regulatory control. The findings demonstrate that expression of Hsp60-Hsp10 enabled successful operation of all essential in vivo functions of GroEL and its co-chaperonin, GroES. Several studies reveal a possible link between members of the Hsp60 family and a number of autoimmune diseases, atherosclerosis and chlamydial disease. Overexpression of self Hsp60 is seen in the synovial tissue of rheumatoid arthritic (RA) patients, and can accompany both cellular and humoral reactivity against Hsp60 in RA. Chlamydial heat shock protein Hsp60, a homolog of E. coli GroEL, appears capable of eliciting macrophage activation, and several studies reveal a correlation between Hsp60 responses and the immunopathologic manifestations of human chlamydial disease.

Applications
Flow

Product Image(s): click to enlarge

Immunogen
Recombinant human Hsp60 protein

Purification
Protein G Affinity

Source
Mouse mAb

Species Reactivity
H, M, R, B, BA

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp60 Monoclonal Antibody (LK-2), PE Conjugate SPA-807PED  
Hsp60 Monoclonal Antibody (LK-2), PE Conjugate SPA-807PEF  

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Citations
Launch Citation Database

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