Hsp90 Beta Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 Beta Recombinant Protein  50 µg SPP-777D $150.00  
Hsp90 Beta Recombinant Protein  200 µg SPP-777F $350.00  
Background
The 90 kDa molecular chaperone family includes 90kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells express inducible Hsp90beta and constitutive Hsp90 beta isoforms that are encoded by separate genes. The amino acid sequences of human and yeast Hsp90 beta are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperonesites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell¿s powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control by serving as a chaperone for many key signaling molecules including steroid receptors, cell cycle kinases involved in signal transduction, and p534. As many of these client proteins are known oncogenes, Hsp90 inhibitors such a s 17-AAG, a geldanamycin analog, have been of benefit in the treatment of many cancers.

Species Reactivity
not applicable

Applications
WB Control

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Source
Recombinant human Hsp90 was cloned from a HeLa cDNA library and expressed in E. coli.

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 Beta Recombinant Protein SPP-777D  
Hsp90 Beta Recombinant Protein SPP-777F  

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Citations
Launch Citation Database

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