nNOS Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
nNOS Polyclonal Antibody  50 µg KAP-NO030D $150.00  
nNOS Polyclonal Antibody  200 µg KAP-NO030F $350.00  
Background
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin following elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucosesensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Source
Rabbit pAb

Applications
WB

Product Image(s): click to enlarge

Species Reactivity
M, R

Immunogen
Synthetic peptide derived from the sequence near the carboxy-terminus of human nNOS

Purification
Protein A Affinity

Host Species
Rabbit pAb

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
nNOS Polyclonal Antibody KAP-NO030D  
nNOS Polyclonal Antibody KAP-NO030F  

Related Products

Product Name Catalog#
Nitric Oxide (total) Detection Kit
 		917-020
Rabbit IgG Polyclonal Antibody, HRP Conjugate
 		SAB-300
eNOS Polyclonal Antibody
 		KAP-NO020
eNOS Polyclonal Antibody
 		KAP-NO021
nNOS (phospho-Ser1417) Polyclonal Antibody
 		KAP-NO032

Citations
Launch Citation Database

Ordering Info
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