Hsc70 (Hsp73) Monoclonal Antibody (1B5), DyLight(TM) 488 Conjugate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp73) Monoclonal Antibody (1B5), DyLight(TM) 488 Conjugate  100 µg SPA-815-488E $325.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Conjugate
DyLight 488

Isotype
IgG2a

Purification
Protein G Affinity

Immunogen
Native hamster Hsc70 (Hsp73) protein

Host
Rat

Clone Number
1B5

Applications
Flow

Species Reactivity
H, M, B, C, CH, R, MO, HA, GP, RB, S, P

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp73) Monoclonal Antibody (1B5), DyLight(TM) 488 Conjugate SPA-815-488E  

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Citations
Launch Citation Database

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