Hsp90 Monoclonal Antibody (AC88), R-Phycoerythrin Conjugate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 Monoclonal Antibody (AC88), R-Phycoerythrin Conjugate  100 µg SPA-830PEE $325.00  
Background
The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells contain isoforms Hsp90 alpha and Hsp90 bete, encoded by separate genes. The amino acid sequences of human and yeast Hsp90 are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 functions as part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control. In this context, researchers identified key regulatory proteins as substrates of Hsp90, including steroid receptors, cell cycle kinases involved in signal transduction, and p53. Hsp90 may act as a capacitor for morphological evolution by buffering widespread variation, potentially affecting morphogenic pathways. When temperature and other stress factors compromise Drosophila Hsp90 buffering, cryptic variant expression occurs, and selection can lead to the continued expression of these traits even after Hsp90 function is restored.

Applications
Flow

Format
PBS, pH 7.2, 0.09% azide

CloneNumber
AC88

HostSpecies
mouse

Purification Method
Protein G Affinity

Species Reactivity
H, M, R, B, C, CH, F

Immunogen
Achlya ambisexualis (water mold) Hsp90 protein

For research use only, not for diagnostic or therapeutic use.

Documentation
SPA-830PE Cert. of Analysis Lot 12040718
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 Monoclonal Antibody (AC88), R-Phycoerythrin Conjugate SPA-830PEE  

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Citations
Launch Citation Database

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