Hsp70 (Hsp72) Monoclonal Antibody (C92F3A-5), R-Phycoerythrin Conjugate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70 (Hsp72) Monoclonal Antibody (C92F3A-5), R-Phycoerythrin Conjugate  100 µg SPA-810PEE $325.00  
Background
The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsp70 cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.

Table of Abbreviations

Clone Number
C92F3A-5

Host Species
mouse

Format
PBS, pH 7.2, 0.09% azide

Applications
Flow

Species Reactivity
H, M, R, B, C, CH, D, F

Purification Method
Protein G Affinity

Immunogen
Native human Hsp70 protein

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
SPA-810PE Cert. of Analysis Lot 12040715
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp70 (Hsp72) Monoclonal Antibody (C92F3A-5), R-Phycoerythrin Conjugate SPA-810PEE  

Related Products

Product Name Catalog#
Hsp70 (Active) Protein - Low Endotoxin
 		ESP-555
Hsp70 (Anti-Human IgG/A/M) ELISA
 		EKS-750
Hsp70 (Hsp72) Monoclonal Antibody (C92F3A-5)
 		SPA-810
Hsp70 (Hsp72) Monoclonal Antibody (C92F3A-5), FITC Conjugate
 		SPA-810FI
Hsp70 ELISA Kit
 		EKS-700B
Hsp70 Polyclonal Antibody
 		SPA-763
Hsp70B prime ELISA Kit
 		EKS-725
Mouse IgG1 Isotype Control, PE Conjugate Monoclonal Antibody
 		SAB-600PE

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134