Septin 5/CDCrel-1 Monoclonal Antibody (SP18)

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Description Size Catalog# Price Quantity  
Septin 5/CDCrel-1 Monoclonal Antibody (SP18) 100 µg  905-781-100 $250.00
Background
Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.

Applications
WB

Product Image(s): click to enlarge

Species Reactivity
H, M, R

Format
PBS, pH 7.2, 50% glycerol, 0.09% azide

Host Species
Mouse

Purification Method
Protein G Affinity

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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