p70 S6K (Rsk) Substrate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p70 S6K (Rsk) Substrate 1mg   SPK-109J $90.00
Background
p70 S6K is a mitogen stimulated serine/threonine protein kinase that regulates the cell growth and G1 phase cell cycle progression. p70 S6K is activated by serum stimulation and can be inhibited by both wortmannin and rapamycin. Activation of p70 S6K by multisite phosphorylation requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s) leading to sequential phosphorylation at two key residues: Thr389 and Thr229. Thr229 phosphorylation is mediated by phosphoinositide-dependent kinase 1 (PDK-1), and is dependent upon prior phosphorylation of Thr389. Multiple residues in the p70 S6K pseudosubstrate domain (e.g. Ser411, Thr421, and Ser424) are also subject to activating phosphorylation by upstream kinases.

Table of Abbreviations

Applications
KA

Species Reactivity
Species Independent

Source
Synthetic p70S6K/Rsk substrate peptide (RRRLSSLA)

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
p70 S6K Recombinant Human Protein
PPK-439

Citations
Launch Citation Database

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