Hsp70 (Hsp72) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70 (Hsp72) Polyclonal Antibody  50 µg SPA-812D $125.00  
Hsp70 (Hsp72) Polyclonal Antibody  200 µg SPA-812F $305.00  
Hsp70 (Hsp72) Polyclonal Antibody  1 mg SPA-812J $1,250.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsp70 pAb

Conjugate

Applications
IP, WB

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Recombinant human Hsp70 protein

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp70 (Hsp72) Protein, NSP-555

Species Reactivity
H, M, R, BE, B, C, F, GP, HA, MO, P, S

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPA-812_LOT-03200632
CofA_SPA-812_LOT-04130718
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp70 (Hsp72) Polyclonal Antibody SPA-812D  
Hsp70 (Hsp72) Polyclonal Antibody SPA-812F  
Hsp70 (Hsp72) Polyclonal Antibody SPA-812J  

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Citations
Launch Citation Database

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