17-DMAG, Hsp90 Inhibitor

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
17-DMAG, Hsp90 Inhibitor 1mg   HPK-118J $195.00
Background
17-Dimethylamino-ethylamino-17-demethoxygeldanamycin (17-DMAG, NSC 707545) is a watersoluble geldanamycin analog belonging to the class of benzoquinones. Geldanamycin analogs such as 17-DMAG bind to the N-terminal domain ATP binding site of Hsp90, inhibiting Hsp90 chaperone activity. Hsp90 client proteins include kinases and several known oncogenes, making inhibition of Hsp90 an attractive chemotherapeutic strategy. Disruption of Hsp90 client protein folding leads to their ubiquitination and subsequent proteolytic degradation by the proteasome. 17-DMAG demonstrates greater potency and water solubility than other geldanamycin analogs such as 17-AAG, while demonstrating anti-tumor activity and offering excellent oral bioavailability.

Table of Abbreviations

Applications
Hsp90 Inhibition

Species Reactivity
Not applicable

Purification
98% (TLC)

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
17-AAG, Hsp90 Inhibitor
HPK-101J
17-GMB-APA-GA, Hsp90 Inhibitor
HPK-119J
AHA1, Activator of Hsp90 (AHSA1) Monoclonal Antibody (1A2-A8)
H00010598-M01
Geldanamycin, Hsp90 Inhibitor
HPK-102J
Hsp90 (water mold) Monoclonal Antibody (AC88)
SPA-830
Hsp90 Antibody Sample Pack
PAK-010
Hsp90 Antibody Sample Pack with Protein Standards
PAK-011
Hsp90 Monoclonal Antibody (16F1)
SPA-835
Hsp90 Native Human Protein
SPP-770
Hsp90 alpha ELISA Kit
EKS-895
Hsp90 alpha Recombinant Human Protein
SPP-776

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134