Neuropeptide Y Receptor (Y1) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Neuropeptide Y Receptor (Y1) Polyclonal Antibody 100 µg  905-798-100 $295.00
Background
Neuropeptide Y (NPY) and the closely related peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino acid, tyrosine-rich peptides with amidated C-terminal ends that are known to regulate gastrointestinal and central nervous system functions including food intake and the inhibition of anxiety. Four functional NPY receptors (Y1/Y2/Y4/Y5) have been identified to date, with a fifth (y6) being a non-functional receptor in primates that is absent from the rat genome. Y1, Y2, and Y5 receptors preferentially bind NPY and PYY, while the Y4 receptor preferentially binds PP. All four receptors signal via coupling to Gi/o alpha subunits, inhibiting adenylyl cyclase activity, thereby decreasing intracellular cAMP levels. Y1 receptor deficient mice display a variety of physical and behavioral phenotypes including obesity, hyperinsulinemia, and increased territorial behavior.

Table of Abbreviations

Abbreviated Name
Neuropeptide Y Receptor pAb

Species Reactivity
H, M, R

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Neuropeptide Y Receptor (Y1)

Host
Rabbit

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For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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