Muscarine Receptor (M2) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Muscarine Receptor (M2) Polyclonal Antibody 100 µg  905-797-100 $295.00
Background
The pharmacologic activity of acetylcholine (ACTH) is mediated by the ionotropic nicotinic receptor or via metabotropic muscarinic receptors. Five known acetylcholine (muscarinic) receptors (M1-M5) are variably expressed in the central nervous system and periphery, mediating motor control, thermoregulation, memory, smooth muscle contraction, glandular secretion, and cardiac function. Although the physiology of the five mammalian muscarinic receptor homologs does not differ significantly in their affinities to a variety of agonists (ACTH, muscarine) and antagonists (e.g., atropine), they can be divided into two sub-groups (M1/M3/M5 and M2/M4) based on G alpha subunit coupling preferences. M1/M3/M5 receptors signal primarily via Gq/11 alpha subunits to stimulate phospholipase C, whereas M2/M4 receptors couple to Gi/o alpha subunits to inhibit adenylyl cyclases and cAMP production. Modulation of muscarinic receptor activity holds promise for the treatment of psychiatric and neurological disorders including schizophrenia and AlzheimerŐs disease.

Table of Abbreviations

Abbreviated Name
Muscarine Receptor pAb

Species Reactivity
R (H, M)

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Muscarine Receptor (M2)

Host
Rabbit

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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