Ghrelin Receptor (GHS-R) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Ghrelin Receptor (GHS-R) Polyclonal Antibody 100 µg  905-792-100 $295.00
Background
Ghrelin is a multifunctional peptide hormone secreted from the anterior pituitary known to affect many physiological processes including the release of growth hormone, appetite regulation, gastric acid secretion, gastrointestinal motility, and blood pressure regulation. The 28 amino acid ghrelin peptide is modified at Ser3 by addition of a fatty acid group (i.e., n-octanoyl) that is essential for its biological activity. The ghrelin receptor (GHS-R) is a seven transmembrane (7-TM) GPCR that is expressed in the hippocampus, pituitary, and hypothalamus, as well as in peripheral tissues including the heart, lung, liver, kidney, pancreas, intestines, and immune cells. Ghrelin signals are primarily relayed via coupling of the GHS-R to Gq/11 alpha subunits, promoting stimulation of phospholipase C, and an increase in intracellular calcium. Stimulation of adenylyl cyclases and increased cAMP are also induced by GHS-R activation. In humans and swine, two splice variants of the ghrelin receptor are expressed from the same gene. The GHS-R 1(a) receptor is the 366 amino acid, 7-TM form, while GHS-R 1(b) is a 289 amino acid, 5-TM form that is truncated at the C-terminus and is pharmacologically inactive. The epitope recognized by this antibody is unaffected by alternative splicing.

Table of Abbreviations

Abbreviated Name
Ghrelin Receptor pAb

Species Reactivity
R (H, M)

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Ghrelin Receptor (GHS-R)

Host
Rabbit

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For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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