Bradykinin Receptor (B1) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Bradykinin Receptor (B1) Polyclonal Antibody 100 µg  905-787-100 $295.00
Background
Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both members of the seven-transmembrane domain-containing G-protein coupled receptor (GPCR) family. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following tissue injury or during inflammation. The B2 receptor displays high affinity for BK and Lys-BK peptide agonists, while the B1 receptor displays highest affinity to des-Arg9-BK and des-Arg10-kallidin. Both receptors are best characterized as signaling via coupling to Gq alpha subunits (particularly Gq/11), leading to activation of phospholipase C beta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.

Table of Abbreviations

Abbreviated Name
Bradykinin Receptor pAb

Species Reactivity
M, R

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Bradykinin Receptor (B1)

Host
Rabbit

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Bradykinin Receptor (B2) Polyclonal Antibody
 		905-747-100
Goat anti-Rabbit IgG Polyclonal Antibody, HRP
 		SAB-300
cyclic AMP (direct) EIA Kit
 		900-066

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134