Adrenergic Receptor (alpha 1b) Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Adrenergic Receptor (alpha 1b) Polyclonal Antibody 100 µg  905-785-100 $295.00
Background
Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression. Adrenoreceptors are classified by three types (alpha 1, alpha 2, and beta) and multiple subclasses based on pharmacological and molecular characteristics. The alpha 1 family consists of three receptor subtypes (alpha 1a, 1b, 1d) which primarily signal via Gq/11 alpha subunits to stimulate Phospholipase C and increase intracellular calcium. In contrast, the three alpha 2 family receptor subtypes (alpha 2a, 2b, 2c) signal via Gi/o alpha subunits to inhibit adenylyl cyclase activity, increase potassium transport, inhibit calcium conductance, and stimulate phospholipase A2. Alpha 1b adrenergic receptor mRNA expression in human tissues is highest in the spleen, kidney, and fetal brain. The alpha 2a receptor is most highly expressed in human brain, spleen, and kidney, and is a species orthologue of the _2d receptor expressed similarly in rat, mouse, and cow.

Table of Abbreviations

Abbreviated Name
Adrenergic Receptor pAb

Species Reactivity
R (H, M)

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Adrenergic Receptor (alpha 1b)

Host
Rabbit

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For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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