Rap1 Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Rap1 Polyclonal Antibody  50 µg KAP-GP120D $125.00  
Rap1 Polyclonal Antibody  200 µg KAP-GP120F $305.00  
Background
The Ras superfamily of small guanosine triphosphatases (GTPases) is traditionally subdivided into five families: Ras, Rho, Rab, Ran, and Arf. Rap1/Krev1 is a member of the Ras family of low molecular weight GTP-binding proteins. Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1 is primarily found at the cytosolic side of intracellular membranes and has two isoforms: Rap1a and 1b. Both isoforms have a molecular mass of 21 kDa and are isoprenylated at the carboxyl-terminal and phosphorylated by the cAMP-dependent protein kinase A (PKA). Rap1 cycles between a GTP-bound active form and a GDP-bound inactive form that is mediated by GTPase activating protein (GAP) and GDP dissociation stimulator (GDS). Activation occurs by a variety of extracellular stimuli through several conserved guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 is proposed to regulate Ras-mediated signaling and may also be involved in the regulation of integrin-mediated cell adhesion, although the mechanism of regulation is not known. Overexpression of Rap reverses the transformed phenotype induced by Ras, possibly by competing with Ras for interaction with Ras-GAP. Rap has been shown to participate in MAP kinase cascade activated by growth factor and maintaining human T cell anergic state by blocking IL-2 expression.

Product Comments
Rap1 Polyclonal Antibody

Applications
WB

Immunogen
Synthetic peptide derived from the N-terminus of human Rap1

Purification
Peptide Affinity

Source
Rabbit pAb

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Rap1 Polyclonal Antibody KAP-GP120D  
Rap1 Polyclonal Antibody KAP-GP120F  

Related Products

Product Name Catalog#
Goat anti-Rabbit IgG Polyclonal Antibody, AP Conjugate
 		SAB-301J
HeLa Cell Lysate
 		LYC-HL100F
Rab3A Polyclonal Antibody
 		KAP-GP003
Rab4 Polyclonal Antibody
 		KAP-GP005
Rap1 Activation Kit
 		EKS-455
Rap1 Polyclonal Antibody
 		KAP-GP125
Rat Brain Tissue Extract
 		LYT-RB100F

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134