Vasopressin Receptor (V1b) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Vasopressin Receptor (V1b) Polyclonal Antibody 100 µg  905-750-100 $295.00
Background
Arginine vasopressin (AVP) is a nonapeptide hormone produced in magnocellular neurons of the hypothalamus, which functions as an antidiuretic in the kidney and systemically as a regulator of vasoconstriction, blood volume, and blood pressure. AVP acts by binding to a set of specific seven transmembrane domain-containing G-protein coupled receptors (GPCR) classified into three groups: V1a (V1), V1b (V3), and V2. V1b receptors stimulate adrenocorticotropic hormone (ACTH) release in the anterior pituitary, but may also participate in corticotropin-releasing hormone (CRH) release by the hypothalamus. The V1b receptor signals through coupling of Gq/11 alpha subunits, activating phospholipase C and release of intracellular Ca2+ via phosphoinositide second messengers. V1b receptor overexpression is a common marker for ACTH-secreting corticotropic adenomas. V2 receptors in the collecting ducts of the kidneys stimulate adenylyl cyclase activity, regulating the reabsorption of water via aquaporin channels.

Table of Abbreviations

Conjugate

Species Reactivity
H, M, R

Applications
IHC, WB, Cellular ELISA

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Vasopressin Receptor (V1b)

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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