Bradykinin Receptor (B2) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Bradykinin Receptor (B2) Polyclonal Antibody 100 µg  905-747-100 $295.00
Background
Bradykinin (BK) is a nine-amino acid peptide produced by kallikrein cleavage of kininogen precursor proteins in tissue and plasma, and is an important regulator of vascular and pain responses to tissue injury. Two receptors (B1 and B2) have been identified as mediators of BK signaling, and are both seven-transmembrane domain-containing GPCRs. The B2 receptor is constitutively expressed in smooth muscle and neurons, whereas B1 expression is induced following injury. B2 receptors signal via Gq alpha subunits, leading to activation of phospholipase Cbeta, hydrolysis of PI, and an intracellular increase in free calcium, although coupling through Gi, Gs, and G12/13 has also been observed.

Table of Abbreviations

Abbreviated Name
Bradykinin Receptor pAb

Conjugate

Species Reactivity
M, R

Applications
IHC, WB, Membrane ELISA

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Bradykinin Receptor (B2)

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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