Cholecystokinin Receptor (CCK1) Polyclonal Antibody

Brand: Proteimax Print Page
Description Size Catalog# Price Quantity  
Cholecystokinin Receptor (CCK1) Polyclonal Antibody 100 µg  905-788-100 $295.00
Background
Cholecystokinin (CCK) is a gastrointestinal peptide hormone released by enteroendocrine cells (I cells) of the small intestine and from specific neurons in the myenteric plexus and brain. CCK is generated from a 115 amino acid prepro-CCK polypeptide that is cleaved to form the largest circulating form, CCK-58. Sequential N-terminal cleavage of CCK-58 generates numerous intermediate CCK peptides (CCK-39, -33, -22, -12, and -8) displaying biological activity. The 5 C-terminal amino acids of CCK are identical to those in gastrin, with both peptides sharing a sulfated C-terminal tyrosine residue. CCK regulates numerous gastric processes, including gallbladder contraction, gastric emptying, intestinal motility, pancreatic exocrine secretion, as well as neurological functions including learning and memory, nociception, and satiety. These functions are carried out via two known CCK receptors, CCK1 and CCK2, that are members of the family A seven transmembrane domain containing G-protein coupled receptors (GPCRs). CCK1 displays preferential binding to sulfated CCK, whereas CCK2 binds both gastrin and CCK with equal affinity. CCK1 receptors are expressed most prominently in the gastrointestinal tract, and myenteric plexus and vagal afferents, while CCK2 is expressed in the brain and stomach. Both CCK1 and CCK2 receptors signal primarily through Gq/11 alpha subunits to simulate phospholipase C and increase intracellular calcium.

Table of Abbreviations

Abbreviated Name
Cholecystokinin Receptor pAb

Species Reactivity
R (H, M)

Applications
WB, Membrane ELISA

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of rat Cholecystokinin Receptor (CCK1)

Host
Rabbit

Product Image(s): click to enlarge

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Dopamine Receptor (D2) Polyclonal Antibody
 		905-740-100
Goat anti-Rabbit IgG Polyclonal Antibody, HRP
 		SAB-300
cyclic AMP (direct) EIA Kit
 		900-066

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134