CTRP7 Polyclonal Antibody

Product Comments
This antibody is suitable for the detection of CTRP7 by WB and ICC in samples from human, mouse, and rat origins. An ~24 kDa band is observed in SDS-PAGE immunoblots. CTRP proteins are often highly modified post-translation and can therefore migrate in SDS-PAGE at positions other than their predicted size.

Applications
ICC, WB

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Species Reactivity
H, M, R

Format
PBS, 0.02% sodium azide

Host Species
Rabbit

Immunogen
Synthetic peptide corresponding to a sequence near the carboxy-terminus of human CTRP7

Positive Control
293 or HL60 Cell Lysates

Purification Method
Peptide Affinity

Significance and Uses
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-α-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Like the other members of the adiponectin and CTRP protein family, the mature CTRP7 is secreted and can be detected in blood.

For research use only, not for diagnostic or therapeutic use.