CTRP3 Polyclonal Antibody

Product Comments
This antibody is suitable for the detection of CTRP3 by WB and IHC in samples from human, mouse, and rat origins. An ~36 kDa protein is observed in SDS-PAGE immunoblots. CTRP proteins are often highly modified post-translation and can therefore migrate in SDS-PAGE at positions other than their predicted size.

Applications
IHC, WB

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Species Reactivity
H, M, R

Format
PBS, 0.02% sodium azide

Host Species
Rabbit

Immunogen
Synthetic peptide derived from the sequence of human CTRP3

Positive Control
mouse heart

Purification Method
Peptide Affinity

Significance and Uses
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-α-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. It has been suggested that CTRP3 may play a role in skeletal development.

For research use only, not for diagnostic or therapeutic use.