Insulin Receptor (phospho-Tyr1322) Monoclonal Antibody (21G12)

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Description Size Catalog# Price Quantity  
Insulin Receptor (phospho-Tyr1322) Monoclonal Antibody (21G12) 100 µg  905-646 $395.00
Background
The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

Table of Abbreviations

Abbreviated Name
Insulin Receptor phospho-Tyr1322 mAb (21G12)

Conjugate

Isotype
IgG1

Product Image(s): click to enlarge

Applications
EIA, WB

Purification
Thiophilic adsorption and size exclusion chromatography

Immunogen
Synthetic phospho-peptide derived from the sequence of Insulin Receptor,conjugated to hemocyanin

Host
Mouse

Clone Number
21G12

Species Reactivity
H, M, C

Positive Control
Pervanadate-treated HEK 293 cells

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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