IGF-I (human) EIA Kit

Applications
EIA

Format
ELISA

Features

• Convenient 4°C storage conditions
• Low cross reactivities to related molecules
• Sensitive to 48.5 pg/mL

Range
187 - 6,000 pg/mL

Sample Size
100 µL

Product Image(s): click to enlarge

Cross Reactivities
human IGF-I 100%
human IGF-II 0.11%

Sample Types
serum, plasma

Samples Per Kit
40 in duplicate per 96 well kit

Sensitivity
48.5 pg/mL

Significance and Uses
Insulin-like growth factor-I (IGF-I) was originally known as Somatomedin C but was later changed to its current name due to its structural similarity to proinsulin. IGF-I has insulin-like effects, but it appears to be involved in many other functions and has been linked to aging, nutrition, physical activity, and cancer. While each of these is very interesting on its own, together they may shed light on the role that lifestyle plays in influencing cancer risk. High levels of circulating IGF-I and low levels of IGF binding protein-3 (IGFBP-3) are associated with increased risk of several cancers. IGF-I can stimulate cell proliferation and inhibit apoptosis in many different kinds of cells. IGF-I circulates in blood bound with IGFBPs. Six IGFBPs have been identified but the majority of circulating IGF-I is complexed with IGFBP-3. The IGF-I and IGFBP-3 exist in a complex with a third protein, named the acid-labile subunit.

Species Reactivity
H

Time To Answer
4 hours

For research use only, not for diagnostic or therapeutic use.