SGKtide Substrate

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
SGKtide Substrate 1mg  SPK-110J $150.00
Background
Serum and glucocorticoid-inducible kinases (SGKs) belong to a family of serine/threonine kinases that are regulated at both the transcriptional and posttranslational levels by external stimuli. SGKs are members of the AGC subfamily that includes the PKC isoforms, cyclic-AMP dependent SGK and p90RSK. There are 3 isoforms, SGK1 and the recently identified SGK2 and SGK3. The transcriptional regulation of the two closely related isoforms, SGK2 and SGK3, are not well known although they can be activated by phosphorylation and SGK3 has been implicated in the IL-3 mediated survival of hematopoietic cells. SGK1 contains a catalytic domain that is ~45-55% homologous to the catalytic domains of SGK, PKB, PKC-zeta and rat p70S6K/p85 S6K kinases which propagate cell signaling cascades associated with the control of cell growth, differentiation and cell survival. The availability and function of SGK1 is regulated at three distinct levels of cellular control. First, SGK1 gene expression is strongly stimulated by hormonal and nonhormonal cues. Second, like PKB, SGK1 is phosphorylated and enzymatically activated as a downstream component of the phosphatidylinositol 3-kinase (PI 3-kinase) signaling cascade that mediates the mitogenic and cell survival responses to many growth factors and insulin. Finally, the subcellular localization of SGK1 is controlled by the cell cycle and exposure to specific hormones and environmental stress stimuli. SGK1 plays an important role in activating certain potassium, sodium and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion.

Table of Abbreviations

Product Comments
This peptide is an appropriate substrate for Assay Designs' Active SGK-1 or SGK-2 (product# PPK-459 or PPK-455)

Species Reactivity
Species Independent

Applications
KA

Format
Lyophilized

Purity
>95% (determined by HPLC)

Source
Synthetic SGKtide substrate peptide (KKRNRRLSVA)

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
SGK-1 (CT) Polyclonal Antibody
 		KAP-PK015
SGK-1 (truncated NT 60 a.a.) Active Recombinant Protein
 		PPK-459
SGK-2 Active Recombinant Protein
 		PPK-455

Citations
Launch Citation Database

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