Rapamycin

Product Comments
Rapamycin binds to and inhibits the FK506 binding protein (FKBP) proline rotamase (1). Rapamycin is bound simultaneously by FKBP12 and FRAP (FKBP12-Rapamycin-Associated-Protein) (2). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity (3), but does inhibit FRAP autophosphorylation (4). Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 to S phase (5,6,7). Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase (8-10).

Species Reactivity
Species Independent

Applications
FK506 binding protein Inhibition

Format
Lyophilized

Purity
98% by TLC analysis

For research use only, not for diagnostic or therapeutic use.