Geldanamycin

Product Comments
Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein 90 (Hsp90) and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1a (3). Geldanamycin is also a potent inhibitor of p60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Geldanamycin also binds to Hsp90 and disrupts Raf-1-HSP90 complex which leads to destabilization of Raf-1 (4-7).

Applications
Hsp90 Inhibition

Species Reactivity
Species Independent

Application Notes
Not sterile

Format
Lyophilized

Purity
>95% as determined by HPLC

For research use only, not for diagnostic or therapeutic use.