Fc fragment of IgE receptor, alpha (FCER1A) Monoclonal Antibody (2C12-3B6)

Brand: Abnova (sold only in the US or Canada) Print Page
Description Size Catalog# Price Quantity  
Fc fragment of IgE receptor, alpha (FCER1A) Monoclonal Antibody (2C12-3B6) 100 ug  H00002205-M01 $285.00
Background
The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139); only the alpha subunit is glycosylated.

Table of Abbreviations

Species Reactivity
H

Isotype
IgG1

Clone
2C12-3B6

Applications
WB

Purification
Protein A Affinity

Tag
GST

Shipping Information
Please allow 1-2 weeks for delivery.

Immunogen
Mouse monoclonal antibody raised against a full length recombinant FCER1A.

Spec Sheet
View Spec Sheet

Related Diseases
allergic disease, hay fever and asthma

Host
Mouse

For research use only, not for diagnostic or therapeutic use.

Documentation

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Citations
Launch Citation Database

Ordering Info
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