Bcl-2 Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Bcl-2 Polyclonal Antibody  100 µg AAS-070E $255.00  
Background
Bcl-2 (B-cell lymphoma 2) is an oncogenic protein that inhibits apoptosis. It is located within the mitochondrial membrane, endoplasmic reticulum and nuclear envelope. Bcl-2 is encoded by a 230 kb gene that results in a 24-26 kDa protein. Bakhshi first identified Bcl-2 as an apoptotic protooncogene while studying chromosomal translocations in human follicular lymphomas. At approximately the same time Tsujimoto and Croce made the same observation. The function of Bcl-2 was first described by Vaux when it was demonstrated that it promoted the survival of factor dependent cells. Bcl-2 overexpression has been implicated in a wide variety of malignancies including (but not limited to) breast, prostate, skin, colon and pancreatic cancers. Related anti-apoptotic proteins include Bcl-xL, Mcl-1 and Bcl-w. Pro-apoptotic proteins in the Bcl-2 family include Bax, BAD, Bak, Blk and Bid.

Applications
IP, WB

Format
Protein A Affinity

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from the sequence of human Bcl-2, conjugated to KLH

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101

Species Reactivity
H, MO

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
Bcl-2 Polyclonal Antibody AAS-070E  

Related Products

Product Name Catalog#
Bad Monoclonal Antibody (5E6)
 		905-638
Bad Polyclonal Antibody
 		AAP-020
Bag-1 Monoclonal Antibody (4A2)
 		AAM-400E
Bak Polyclonal Antibody
 		AAP-030
Bcl-2 (human total) EIA Kit
 		900-133
Bcl-2 Monoclonal Antibody (83-8B)
 		AAM-072E
Bcl-2alpha Monoclonal Antibody (SPM117)
 		905-328
Bcl-w Polyclonal Antibody
 		AAP-050
Bim/BOD Polyclonal Antibody
 		AAP-330
HeLa Cell Lysate (Heat Shocked)
 		LYC-HL101F
Mcl-1 rabbit polyclonal antibody
 		905-460

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134