Bcl-2 Monoclonal Antibody (83-8B)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Bcl-2 Monoclonal Antibody (83-8B) 100 µg  AAM-072E $295.00
Background
Bcl-2 (B-cell lymphoma 2) is an oncogenic protein that inhibits apoptosis. It is located within the mitochondrial membrane, endoplasmic reticulum and nuclear envelope. Bcl-2 is encoded by a 230 kb gene that results in a 24-26 kDa protein. Bakhshi first identified Bcl-2 as an apoptotic protooncogene while studying chromosomal translocations in human follicular lymphomas. At approximately the same time Tsujimoto and Croce made the same observation. The function of Bcl-2 was first described by Vaux when it was demonstrated that it promoted the survival of factor dependent cells. Bcl-2 overexpression has been implicated in a wide variety of malignancies including (but not limited to) breast, prostate, skin, colon and pancreatic cancers. Related anti-apoptotic proteins include Bcl-xL, Mcl-1 and Bcl-w. Pro-apoptotic proteins in the Bcl-2 family include Bax, BAD, Bak, Blk and Bid.

Applications
WB, Flow

Format
Purified (Protein A)

CloneNumber
83-8B

HostSpecies
mouse

Immunogen
Recombinant rat Bcl-2 beta protein

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

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Citations
Launch Citation Database

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