Bax Monoclonal Antibody (4F11)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Bax Monoclonal Antibody (4F11) 100 µg  AAM-140E $295.00
Background
Many physiological processes, including cellular development and homeostasis, are regulated by a balance between cell proliferation, differentiation and apoptosis. Several gene products play a significant role in regulating apoptosis. The Bcl-2 gene family is comprised of both pro-apoptotic (e.g. Bax, Bid) and anti-apoptotic (e.g. Bcl-2, Bcl-XL) members, with membership dependent on the presence of at least one Bcl-2 homology (BH) domain. These proteins form homo- and heterodimers, with the ratio between pro- and anti-apoptotic levels an important determinant of cell survival. Bax is a 21 kDa protein that accelerates apoptosis by binding to, and antagonizing the death repressor activity of Bcl-2 in vivo. Bax normally resides in the cytoplasm, but following an apoptotic stimuli, Bax undergoes a conformational change and translocates to mitochondrial membranes, where it inserts and mediates the release of cytochrome c from the intermembrane space into the cytosol, in this manner activating caspase 3 and perpetuating the apoptotic cascade. Protein levels of Bax and other Bcl-2 family members are altered in various human malignancies, with changes in expression levels implicated in diseases involving apoptosis such as cancer, autoimmune diseases and neurodegenerative disorders.

Table of Abbreviations

Applications
IHC, IP, WB

Format
Purified (Protein A)

CloneNumber
4F11

HostSpecies
mouse

Immunogen
Recombinant human Bax protein

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

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Citations
Launch Citation Database

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