Apaf-1 (CT) Polyclonal Antibody

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Description Size Catalog# Price Quantity  
Apaf-1 (CT) Polyclonal Antibody 100 µg  905-179 $295.00
Background
Apaf-1 (Apoptosis protease-activating factor 1), a mammalian protein homologous to C. elegans CED-4, is an essential adaptor molecule and a key linker of the mitochondrial apoptotic pathway. Apaf-1 binds to Cytochrome c (Apaf-2) leading to the formation of a large multimeric complex. This complex recruits (through CARD) Procaspase-9 and once activated, caspase-9 (Apaf-3) dissociates. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf-1 can also associate with caspase-4, caspase-8 and Diva. Apaf-1 is ubiquitously expressed in human tissues.

Table of Abbreviations

Applications
IHC, WB

Product Image(s): click to enlarge

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human Apaf1

PurificationMethod
Affinity purified

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

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Citations
Launch Citation Database

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