Survivin (human total) EIA Kit

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Description	Size	Catalog#	Price	Quantity
Survivin (human total) EIA Kit	1x96 well	900-111	$625.00

Background

Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.

Table of Abbreviations

Applications
EIA

Features

Only complete Survivin immunoassay kit on the market
Much less time consuming than Western blotting

Range
31.25 - 1,000 pg/mL

Sample Size
100 無

Product Image(s): click to enlarge

Cross Reactivities
human Survivin 100%
There is less than 0.1% cross-reactivity with human MEK-1, pJNK, p300, Granzyme B, Caspase-3, or Caspase-9.

Sample Types
culture media, jurkat cell lysate 4 million cells/mL, serum, heparin plasma, urine

Samples Per Kit
40 in duplicate per 96 well kit

Sensitivity
4 pg/mL

Species Reactivity
H

Time To Answer
3 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
AssayLayout
Kit Insert
MSDS

Related Products

Product Name	Catalog#
Annexin V-FITC Kit	ADK-700E
Annexin V-FITC kit	ADK-700F
Assay Buffer 20, 100 mL	80-1029
Bax (human) EIA Kit	900-138
Bcl-2 (human total) EIA Kit	900-133
Creatinine Colorimetric Detection Kit	907-030
DePsipher Kit	900-167
Stop Solution 2, 10 mL	80-0377
Survivin Polyclonal Antibody	AAP-275
TMB Substrate, 10 mL	80-0350
Wash Buffer Concentrate, 100 mL	80-1287
XIAP Monoclonal Antibody (2F1)	AAM-050E

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134

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Survivin (human total) EIA Kit