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ATF6 Polyclonal Antibody

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Description Size Catalog# Price Quantity  
ATF6 Polyclonal Antibody 100 µg   905-729-100 $285.00
Background
Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone Grp78, but upon ER stress is released from Grp78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus. Nuclear ATF6, together with the transcription factor XBP-1, activates transcription of UPR-responsive genes.

Table of Abbreviations

Applications
ICC, WB

Species Reactivity
H, M

Conjugate

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Peptide Affinity

Immunogen
Synthetic peptide corresponding to sequence near the amino-terminus of human ATF6

Host
Rabbit

Clone Number
not applicable

Positive Control
MDA-MB-361 Cell Lysates

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

Ordering Info
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