Amyloid beta A4 (CT, 1-42) Monoclonal Antibody (8G7)

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Description	Size	Catalog#	Price	Quantity
Amyloid beta A4 (CT, 1-42) Monoclonal Antibody (8G7)	100 痢	905-804	$320.00

Background

The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), provides the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/ nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).

Table of Abbreviations

Applications
EIA, ICC, WB

Species Reactivity
H

Isotype
IgG1

Purification
Thiophilic adsorption and size exclusion chromatography

Immunogen
C-terminal peptide conjugated to KLH; C-Terminus of Amyloid beta A4 (1-42), does not cross react with beta A4 (1-40)

Host
Mouse

Clone Number
8G7

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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Amyloid beta A4 (CT, 1-42) Monoclonal Antibody (8G7)