8-iso-PGF2alpha Polyclonal Antibody

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Description Size Catalog# Price Quantity  
8-iso-PGF2alpha Polyclonal Antibody 100 µL  905-016 $255.00
Background
The 8-epimer of Prostaglandin F2alpha (8-iso-PGF2alpha) is produced in vivo by both non-cyclooxygenase and cyclooxygenase dependant mechanisms from arachidonic acid. 8-iso-PGF2alpha has been shown to be a potent vasoconstrictor, a potential mediator of hepatorenal syndrome and atherosclerosis and a mutagen in 3T3 cells and in vascular smooth muscle cells. It has also been postulated to participate as a pathophysiological mediator and is able to modify the fluidity and integrity of membranes. 8-iso-PGF2alpha has been shown to circulate in plasma and is excreted in urine. Methods for assessing total 8-iso-PGF2alpha typically require the alkaline hydrolysis of 8-iso-PGF2alpha esters from tissues, followed by length procedures involving extractions, phase separations and thin layer chromatography.

Applications
EIA

Cross Reactivities
8-iso-PGF2a 100%
PGF1a 84.0%
PGF2a 5.0)%
PGE1 0.10%
6-keto-PGF1a 0.10%
TXB2 0.03%
13,14-dihydro-15-keto-PGF2a <0.01%
PGE3 <0.01%
PGB1 <0.01%
PGA2 <0.01%
6,15-diketo-13,14-dihydro-PGF1a <0.01%

HostSpecies
rabbit

Immunogen
8-iso-Prostaglandin F2alpha conjugated to porcine thyroglobulin

Species Reactivity
Species Independent

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
8-iso-PGF2alpha Polyclonal Antibody
 		905-015

Citations
Launch Citation Database

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