PGE2 CLIA Kit

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Description Size Catalog# Price Quantity  
PGE2 CLIA Kit 1x96 well   910-001 $345.00
Background
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

Normalize urine samples to creatinine with our Creatinine Colorimetric Detection Kit.

Table of Abbreviations

Applications
EIA

Species Reactivity
Species Independent

Features

  • Validated in numerous sample matrices
  • Results in just 3 hours
  • Sensitive to 6.03 pg/mL

Range
7.81 - 1,000 pg/mL

Sample Size
100 µL

Product Image(s): click to enlarge

Cross Reactivities
PGE2 100%
PGE1 70.0%
PGE3 16.3%
PGF1alpha 1.40%
PGF2alpha 0.70%
6-keto-PGF1alpha 0.60%
PGA2 0.10%
PGB1 0.10%
<0.10%: 13,14-dihydro-15-keto-PGF2alpha / 6,15-keto-13,14-dihydro-PGF1alpha / Thromboxane B2 / 2-Arachidonoylyglycerol / Anandamide / PGD2 / Arachidonic Acid

Sample Types
culture media, saliva, serum, urine, whole blood

Samples Per Kit
36 in duplicate per 96 well kit

Sensitivity
6.03 pg/mL

Time To Answer
3 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
AssayLayout
Kit Insert
MSDS

Related Products

Product Name Catalog#
COX Activity Kit
907-003
Creatinine Colorimetric Detection Kit
907-030
PGE2 EIA Kit
900-001
PGE2 EIA Kit
901-001
PGE2 FPIA Kit
920-001
PGE2 High Sensitivity EIA Kit
930-001
PGE2 High Sensitivity EIA Kit
931-001
PGE2 Monoclonal Antibody (BG8)
905-628
PGE2 Receptor (EP2) Polyclonal Antibody
905-899-100
TXB2 EIA Kit
900-002

Citations
Launch Citation Database

Ordering Info
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Order by fax: 734-669-0134