Catenin-beta (total) EIA Kit

Applications
EIA

Format
ELISA

Features

• Only complete beta-catenin immunoassay kit on the market
• Thoroughly validated in cell lysates

Range
125 - 8,000 pg/mL

Sample Size
100 µL

Product Image(s): click to enlarge


Cross Reactivities
Beta-Catenin 100%
<0.1%: cIAP1 / Smac/DIABLO / p300 / MEK2 / GSK-3beta

Sample Types
RIPA Cell Lysis Buffer

Samples Per Kit
39 in duplicate per 96 well kit

Sensitivity
26.8 pg/mL

Significance and Uses
Beta-catenin is a 781 amino acid adherens junction protein that plays an important role in two unrelated cellular functions. Adherens junctions are critical for establishment and maintenance of epithelial layers, such as those found lining the surface of organs. Involved in both cell-cell adhesion and in the wnt/wg signaling pathway, beta-catenin can be found in the cytoplasm or the nucleus. In the cytoplasm, beta-catenin is unstabilized by phosphorylation and association with E-cadherin. When beta-catenin translocates to the nucleus, it has comparatively low levels of phosphorylation. Wnt/wg signaling results in beta-catenin accumulation and transcriptional activation of specific target genes during development. Deregulation of beta-catenin signaling is an important event in the evolution a number of malignancies, including colon cancer, melanoma, ovarian cancer, and prostate cancer.

Species Reactivity
H, M, R

Time To Answer
3 hours

For research use only, not for diagnostic or therapeutic use.