Hsc70 (Hsp70) Monoclonal Antibody (N27F3-4), AP

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp70) Monoclonal Antibody (N27F3-4), AP  200 µL SPA-820APF $395.00  
Hsc70 (Hsp70) Monoclonal Antibody (N27F3-4), AP  50 µL SPA-820APD $165.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsc70 mAb, AP (N27F34)

Applications
WB

Conjugate
AP

Isotype
IgG1

Species Reactivity
H, M, R, B, C, CH, F

Purification
Ion Exchange

Immunogen
Native human Hsp70/Hsc70 protein

Host
Mouse

Clone Number
N27F34

PositiveControls
HeLa Cell Lysate, LYC-HL100 Hsc70 (Hsp73) Protein, SPP-751 Hsp70 (Hsp72) Protein, NSP-555

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPA-820AP_LOT-04190614

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp70) Monoclonal Antibody (N27F3-4), AP SPA-820APF   Spec Sheet   
Hsc70 (Hsp70) Monoclonal Antibody (N27F3-4), AP SPA-820APD   Spec Sheet   

Related Products

Product Name Catalog#
Hsc70 (Hsp70) Polyclonal Antibody
 		SPA-757

Citations
Launch Citation Database

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