Hsp90 alpha Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 alpha Recombinant Protein  20 µg SPP-776B $115.00  
Hsp90 alpha Recombinant Protein  50 µg SPP-776D $155.00  
Hsp90 alpha Recombinant Protein  200 µg SPP-776F $365.00  
Background
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Expression System
Recombinant human Hsp90 was cloned from a HeLa cDNA library and expressed in E. coli.

Species Reactivity
not applicable

Applications
WB Control

Purification
Multi-step chromatography

Source
Human

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 alpha Recombinant Protein SPP-776B  
Hsp90 alpha Recombinant Protein SPP-776D  
Hsp90 alpha Recombinant Protein SPP-776F  

Related Products

Product Name Catalog#
Hsp90 Beta Recombinant Protein
 		SPP-777
Geldanamycin
 		HPK-102J
HeLa Cell Lysate (Heat Shocked)
 		LYC-HL101F
Hsp90 Monoclonal Antibody (AC88)
 		SPA-830
Hsp90 Monoclonal Antibody (16F1)
 		SPA-835
Hsp90 Monoclonal Antibody (AC88), DyLight(TM) 488 Conjugate
 		SPA-830-488
Hsp90 Monoclonal Antibody (AC88), R-Phycoerythrin Conjugate
 		SPA-830PE
Hsp90 Native Protein
 		SPP-770
Hsp90 Polyclonal Antibody
 		SPA-836
Hsp90 alpha ELISA Kit
 		EKS-895
Hsp90 alpha Monoclonal Antibody (9D2)
 		SPA-840
Rabbit anti-Rat IgG Polyclonal Antibody, HRP Conjugate
 		SAB-200J

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134