Hsp90 alpha Monoclonal Antibody (9D2)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 alpha Monoclonal Antibody (9D2)  200 µg SPA-840F $325.00  
Hsp90 alpha Monoclonal Antibody (9D2)  50 µg SPA-840D $130.00  
Background
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Conjugate

Applications
Flow, IHC, WB

Isotype
IgG2a

Purification
Protein G Affinity

Immunogen
Native human Hsp90 protein

Host
Rat

Clone Number
9D2

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp90 Alpha Protein, SPP-776 Hsp90 Protein, SPP-770

Species Reactivity
H, CH

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 alpha Monoclonal Antibody (9D2) SPA-840F  
Hsp90 alpha Monoclonal Antibody (9D2) SPA-840D  

Related Products

Product Name Catalog#
HO-1 (Hsp32) Polyclonal Antibody
 		SPA-896
Hsp90 Native Protein
 		SPP-770
Hsp90 alpha ELISA Kit
 		EKS-895
Hsp90 alpha Monoclonal Antibody (9D2), HRP
 		SPA-840HRP
Hsp90 alpha Polyclonal Antibody
 		SPS-771
Hsp90 alpha Recombinant Protein
 		SPP-776

Citations
Launch Citation Database

Ordering Info
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