Beclin-1 Polyclonal Antibody

Product Comments
This antibody is suitable for the detection of Beclin-1 by WB and IHC in samples from human, mouse, and rat origins. An ~57 kDa band is observed in SDS-PAGE immunoblots.

Applications
IHC, WB

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Species Reactivity
H, M, R

Format
PBS, 0.02% sodium azide

Host Species
Rabbit

Immunogen
Synthetic peptide corresponding to a sequence near the amino-terminus of human Beclin-1

Positive Control
rat brain

Purification Method
Peptide Affinity

Significance and Uses
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Beclin-1, a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6, is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as an anti-autophagy protein, as well as an anti-apoptotic protein that helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.

For research use only, not for diagnostic or therapeutic use.