Hsc70 (Hsp73) Active Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp73) Active Recombinant Protein  50 µg SPP-751D $200.00  
Hsc70 (Hsp73) Active Recombinant Protein  200 µg SPP-751F $550.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Species Reactivity
not applicable

Applications
AA, WB Control

Format
Recombinant bovine Hsc70 in 30mM Tris-HCl pH 7.5, 300mM NaCl, 2mM DTT, 1mM EDTA

Purity
~85% (SDS-PAGE)

Source
Recombinant bovine Hsc70 expressed in E. coli.

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp73) Active Recombinant Protein SPP-751D  
Hsc70 (Hsp73) Active Recombinant Protein SPP-751F  

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Citations
Launch Citation Database

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