Hsp27 ELISA Kit

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsp27 ELISA Kit	1x96 well	EKS-500	$575.00

Background

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

Table of Abbreviations

Applications
EIA

Range
0.39 - 25 ng/mL

Sample Size
100無/well

Product Image(s): click to enlarge

Sample Types
cell lysates, tissue extracts, serum, plasma

Samples Per Kit
39 samples in duplicate per 96 well kit

Sensitivity
0.39 ng/mL

Species Reactivity
H

Time To Answer
< 3 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert

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Citations
Launch Citation Database

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Hsp27 ELISA Kit