Hsp70 (Anti-Human IgG/A/M) ELISA

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70 (Anti-Human IgG/A/M) ELISA 1x96 well  EKS-750 $575.00
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Applications
ELISA

Format
ELISA

Range
31.25 - 1,000 ng/mL

Sample Size
100µL/well

Sample Types
serum

Samples Per Kit
41 samples in duplicate per 96 well kit

Sensitivity
6.79 ng/mL

Species Reactivity
H

Time To Answer
< 4 hours

For research use only, not for diagnostic or therapeutic use.

Documentation
Kit Insert

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Hsp70 ELISA Kit
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Stop Solution 2
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Citations
Launch Citation Database

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