HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)	100 痢	OSA-110E	$345.00
HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)	1 mg	OSA-110J	$2,400.00

Background

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Table of Abbreviations

Abbreviated Name
HO-1 mAb (HO-1-1)

Conjugate

Applications
Flow, WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of human HO-1 (Hsp32)

Product Image(s): click to enlarge

Host
Mouse

Clone Number
HO-1-1

PositiveControls
Human HO-1 (Hsp32) Protein, SPP-732Rat HO-1 (Hsp32) Protein, SPP-730

Species Reactivity
H, M, R, B, C

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_OSA-110_LOT-10040708
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)	OSA-110E
HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)	OSA-110J

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Product Name	Catalog#
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HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), DyLight 488	OSA-111-488
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), PE	OSA-111PE
HO-1 (Hsp32) Polyclonal Antibody	SPA-895
HO-1 (Hsp32) Polyclonal Antibody	SPA-896
HO-1 (Hsp32) Polyclonal Antibody	SPA-894
HO-1 (Hsp32) Recombinant Human Protein	SPP-732
HO-1 (Hsp32) Recombinant Rat Protein	SPP-730
HO-1 (Human) ELISA Kit	EKS-800
HO-1 (Rat) ELISA Kit	EKS-810A
HO-1 (mouse) ImmunoSet	960-071
HO-1 (rat) ImmunoSet	960-810
Mouse Liver Microsome Extract	LYT-MM100F
Transferrin Polyclonal Antibody	VAP-EN004

Citations
Launch Citation Database

Ordering Info
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HO-1 (Hsp32) Monoclonal Antibody (HO-1-1)