Tumor necrosis factor alpha (TNF-alpha)

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Description Size Catalog# Price Quantity  
Tumor necrosis factor alpha (TNF-alpha)  50 µg HYB 141-09-S $145.00  
Tumor necrosis factor alpha (TNF-alpha)  200 µg HYB 141-09-02 $430.00  
Tumor necrosis factor alpha (TNF-alpha)  1 mg HYB 141-09-1 $1,970.00  
Background
Tumor necrosis factor alpha (TNFalpha), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.

Table of Abbreviations

Conjugate

Shipping Information
Please allow 1-2 weeks for delivery.

Species Reactivity
H

Applications
EIA

Isotype
IgG1

Purification
Protein A/G Affinity

Immunogen
(see spec sheet)

Host
Mouse

Clone Number
not available

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Tumor necrosis factor alpha (TNF-alpha) HYB 141-09-S  
Tumor necrosis factor alpha (TNF-alpha) HYB 141-09-02  
Tumor necrosis factor alpha (TNF-alpha) HYB 141-09-1  

Related Products

Product Name Catalog#
Tumor necrosis factor alpha (TNF-alpha)
 		HYB 141-08

Citations
Launch Citation Database

Ordering Info
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